association between anti-iga antibody and development of adverse reactions in immunodeficient patients under immunoglobulin therapy

background: mild to severe post-transfusion adverse reactions have been reported in a proportion of immunodeficient patients receiving intravenous immunoglobulin (ivig). anti-iga antibody has been proposed to be associated with development of such reactions.   objective: to assess the association between anti-iga levels of different isotypes and adverse reactions induced in immunodeficient patients following infusion of ivig.   methods: in this study, igm, igg and ige anti-iga antibodies were measured by an indirect elisa method in serum samples from 31 patients with a variety of immunodeficiencies receiving ivig and 24 normal individuals. results: anti-iga antibody of all three isotypes were detectable in all sera. however, when presented as proportion of total iga (anti –iga/total iga)igg, ige isotypes are significantly higher in patients with adverse reactions compared to those without reactions or normal subjects. conclusion: both igg and ige anti-iga antibodies may contribute to the development and severity of adverse reactions in some patients receiving ivig.